C6Medline
Free Radic
Res Commun 1990;11(1-3):109-15
Studies on the antioxidant and free radical scavenging properties
of IdB 1016 (Siliphos®) (Siliphos®) a new flavanolignan
complex.
Comoglio A, Leonarduzzi G, Carini R, Busolin D, Basaga H, Albano
E, Tomasi A, Poli G, Morazzoni P, Magistretti MJ
See
National Library of Medicine Citation
Department of Experimental Medicine and Oncology, University of
Turin, Italy.
Silybin has been complexed in 1:1 ratio with phosphatidyl choline
to give IdB 1016 (Siliphos®) in order to increase its bioavailability.
The antioxidant and free radical scavenger action of this new form
of silybin has been evaluated. One hour after the intragastric
administration to rats of IdB 1016 (Siliphos®) IdB decreased
by about 40% the lipid peroxidation induced in microsomes by NADPH,
CCl4 and cumene hydroperoxide, probably by acting on lipid derived
radicals.
Spin trapping experiments showed, in fact, that the complexed
form of silybin was able to scavenge lipid dienyl radicals generated
in the microsomal membranes. In addition, IdB 1016 (Siliphos®)
was also found to interact with free radical intermediates produced
during the metabolic activation of carbon tetrachloride and methylhydrazine.
These effects indicate IdB 1016 (Siliphos®) as a potentially
protective agent against free radical-mediated toxic damage.
PMID: 2074043, UI: 91161019
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